Monocyte chemoattractant protein-1 gene (MCP-1) polymorphisms are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study
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- 作者：Javier Angeles-Martí ; neza ; jabojangeles@yahoo.com.mx" class="auth_mail" title="E-mail the corresponding author ; Rosalinda Posadas-Sá ; nchezb ; rossy_posadas_s@yahoo.it" class="auth_mail" title="E-mail the corresponding author ; Edith Á ; lvarez-Leó ; na ; edalvaleo@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Teresa Villarreal-Molinac ; mtfvillarreal@yahoo.com.mx" class="auth_mail" title="E-mail the corresponding author ; Guillermo Cardoso-Saldañ ; ab ; gccardosos@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; José ; Manuel Fragosoa ; mfragoso1275@yahoo.com.mx" class="auth_mail" title="E-mail the corresponding author ; Juan Gabriel Juá ; rez-Rojasb ; gaboyk2@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Aida Medina-Urrutiab ; aidaxm@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Carlos Posadas-Romerob ; cposadasr@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Gilberto Vargas-Alarcó ; na ; gvargas63@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIMs ; ancestry informative markers ; ANCOVA ; analysis of covariance ; ANOVA ; analysis of variance ; CAC ; coronary artery calcification ; CAD ; coronary artery disease ; EDTA ; ethylenediaminetetraacetic acid ; GEA ; genetics of atherosclerotic disease ; GGT ; gamma-glutamyl transpeptidase ; LD ; linkage disequilibrium ; LSAR ; hepatic to splenic attenuation ratio ; MCP1 ; monocyte chemoattractant protein1 ; MI ; myocardial infarction ; PCR ; polymerase chain reaction ; SNP ; single nucleotide polymorphism ; T2DM ; type
- 刊名：Immunology Letters
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：167
- 期：2
- 页码：125-130
- 全文大小：300 K
文摘
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The MCP-1 rs1024610 polymorphism was associated with increased risk of developing premature CAD in patients without type 2 diabetes mellitus.
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The MCP-1 rs3760396 CC genotype was associated with low levels of gamma-glutamyl transpeptidase (P = 0.002) in premature CAD patients.
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The MCP-1 rs1024610 TT genotype was associated with decreased risk of T2DM (P = 0.035) in premature CAD patients.
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One MCP-1 haplotype (CATG) was associated with increased risk of developing premature CAD (OR = 1.44, P = 0.0019).