Expression of protease-activated receptor 1 in oral squamous cell carcinoma

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• 作者：Liu ; Yanna ; Gilcrease ; Michael Z. ; Henderson ; Ying ; Yuan ; Xiao H. ; Clayman ; Gary L. ; Chen ; Zhuo
• 关键词：Protease-activated receptor ; Thrombin ; Squamous cell carcinoma ; Matrix metalloproteinase ; Metastasis
• 刊名：Cancer Letters
• 出版年：2001
• 出版时间：August 28, 2001
• 年：2001
• 卷：169
• 期：2
• 页码：173-180
• 全文大小：1019 K

文摘

Protease-activated receptor 1 (PAR-1) is a G-coupled membrane protein. In this study, we analyzed the expression of PAR-1 in oral squamous cell carcinomas (SCCs). PAR-1 was expressed in oral SCCs, but the level of PAR-1 protein was lower in non-metastatic cells than in metastatic cells. Thrombin stimulated the growth of metastatic cells, and both thrombin and thrombin receptor activation peptide (TRP) enhanced the adhesion of these cells to fibronectin, but had no effect on non-metastatic cells. Thrombin and TRP also induced matrix metalloproteinase (MMP)-2 and MMP-9 activities in metastatic cells. These results suggest that PAR-1 may contribute to the growth and invasive potential of oral SCC.