Lipomatous variant of myofibroblastoma with epithelioid features: a rare and diagnostically challenging breast lesion

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• 作者：Mary M.  ; Wahbah MD^a ; Michael Z.  ; Gilcrease MD ; PhD^a ; Yun  ; Wu MD ; PhD ;   ; ^a ;   ; ^{yunwu@mdanderson.org}
• 关键词：Myofibroblastoma ; Breast ; Lipomatous variant
• 刊名：Annals of Diagnostic Pathology
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：15
• 期：6
• 页码：454-458
• 全文大小：2194 K

文摘

Myofibroblastoma of the breast is an unusual benign spindle cell tumor composed of cells with histologic, immunohistochemical, and ultrastructural features of myofibroblasts. In addition to the classic form, a few variants of myofibroblastoma have been described. Recognition of these variants is important to prevent overdiagnosis of a malignant lesion, especially on core biopsy. Three variants that can cause particular confusion on core biopsy are the lipomatous, infiltrative, and epithelioid variants of myofibroblastoma. Thus far, there have been only a few reports of these variants in the English literature. We report a rare case of a lipomatous variant of myofibroblastoma with an epithelioid cell component and discuss the differential diagnosis and potential diagnostic pitfalls.