The effect of cisplatin dose and surgical resection in children with malignant germ cell tumors at the sacrococcygeal region: A Pediatric Intergroup Trial (POG 9049/CCG 8882)
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Background/Purpose: A disproportionally high incidence of true hermaphroditism is seen among the South African black people, constituting 51 % of children in local study on all intersex types. These patients were different from the commonly reported patients with true hermaphroditism in that the common gonad was a mixed type of ovotestis, making the management of such patients problematic. The aim of this study was to establish a protocol for the management for children with true hermaphroditism in Southern Africa. Methods: Seventy-one children, over a 16-year period, were diagnosed with true hermaphroditism. After a decision on the child gender status, part of the management consisted of excision of all discordant and ovotesticular gonadal tissue. The histology of these gonads was then compared with the initial biopsy results. Results: The histology of the initial gonadal biopsies showed that 55 % of all gonads were ovotestes, 26 % were ovaries, and 19 % testes. Thirty-five patients had 44 gonads excised. Comparing the 2 sets of histology showed that the initial histology of the discordant gonads was insufficient to show all the ovotesticular tissue in 22 % of gonads. Initial biopsies that showed testicular tissue only were misdiagnosed in 82 % of cases. Conclusion: It is suggested that, in Southern African true hermaphrodites, all ovotestes, discordant gonads, and all gonads that show only testicular tissue be excised as part of the initial corrective management. J Pediatr Surg 36:397-399. Copyright © 2001 by W.B. Saunders Company.

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