Psychological Effects of False-Positive Results in Cystic Fibrosis Newborn Screening: A Two-Year Follow-Up

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• 作者：Julie Beucher ; Emmanuelle Leray ; Eric Deneuville ; Monique Roblin ; Isabelle Pin ; Franç ; ois Bremont ; Dominique Turck ; Jean-Louis Giniè ; s ; Pascal Foucaud ; Gilles Rault ; Jocelyne Derelle ; Valé ; rie David ; Hubert Journel ; Sophie March ; David Veillard ; Michel Roussey
• 刊名：The Journal of Pediatrics
• 出版年：2010
• 出版时间：May 2010
• 年：2010
• 卷：156
• 期：5
• 页码：771-776.e1
• 全文大小：226 K

文摘

Objective

To evaluate parental stress after a false-positive result at the time of the cystic fibrosis (CF) newborn screening (NBS), attributable to heterozygotism or persistent hypertrypsinemia.

Study design

A prospective study was conducted in 86 French families at 3, 12, and 24 months after NBS. A psychologist conducted interviews with a questionnaire, the Perceived Stress Scale, and the Vulnerable Child Scale.

Results

Overall, 96.5 % of parents said they had been anxious at the time of the sweat test. However, 86 % felt entirely reassured 3 months after the test. The mean Perceived Stress Scale score did not differ from that observed in the French population. Mean Vulnerable Child Scale scores were high, associated with a low Parental Perception of Child Vulnerability. These results did not differ significantly at 1 and 2 years. In total, 86 % to 100 % of families no longer worried about CF. All parents stated that they would have the test performed again for another child.

Conclusions

CF NBS can lead to false-positive results, causing parental anxiety, which quickly decreases after a sweat test performed soon after the phone call.