Liver fibrosis in treatment-naïve HIV-infected and HIV/HBV co-infected patients: Zambia and Switzerland compared
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- 作者：Gilles Wandelera ; b ; gilles.wandeler@ispm.unibe.ch" class="auth_mail" title="E-mail the corresponding author ; Lloyd Mulengac ; d ; Michael J. Vinikoorc ; e ; Helen Kovarif ; Manuel Battegayg ; Alexandra Calmyh ; Matthias Cavassinii ; Enos Bernasconij ; Patrick Schmidk ; Carolyn Bolton-Moorec ; e ; Edford Sinkalad ; Benjamin H. Chic ; Matthias Eggerb ; l ; Andri Raucha ; for IeDEA-Southern Africa ; the Swiss HIV Cohort Study
- 关键词：Hepatitis B infection ; HIV ; Liver fibrosis ; Switzerland ; Zambia
- 刊名：International Journal of Infectious Diseases
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：51
- 期：Complete
- 页码：97-102
- 全文大小：573 K
文摘
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This was a cross-sectional study of HIV-infected, antiretroviral therapy-naïve adults in Zambia and Switzerland.
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HIV/hepatitis B virus (HBV) co-infected patients are at least three times more likely to have significant liver fibrosis compared to HIV monoinfected individuals.
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The association between HBV and liver fibrosis seems to be driven by HBV viral load.
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The main risk factors for liver fibrosis are similar in Switzerland and Zambia.