Uliginosin B presents antinociceptive effect mediated by dopaminergic and opioid systems in mice

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• 作者：Eveline Dischkaln Stolz ; Alice Fialho Viana ; Diego Rafael Hasse ; Gilsane Lino von Poser ; Jean-Claude do Rego ; Stela M.K. Rates
• 关键词：13C RMN ; carbon nuclear magnetic resonance ; 1H RMN ; proton nuclear magnetic resonance ; ANOVA ; analysis of variance ; CGEN ; Conselho de Gestã ; o do Patrimô ; nio Gené ; tico ; CIOMS ; Council for International Organization of Medical Sciences Inte
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2012
• 出版时间：1 October, 2012
• 年：2012
• 卷：39
• 期：1
• 页码：80-87
• 全文大小：768 K

文摘

Previous studies have shown that uliginosin B inhibits dopamine reuptake in rat brain. This compound occurs in Hypericum polyanthemum and H. caprifoliatum for which was reported to have antinociceptive effect sensitive to naloxone. The aim of this study was to assess the antinociceptive effect of uliginosin B and to evaluate the involvement of opioid and dopaminergic receptors activation. Uliginosin B presented antinociceptive effect in hot-plate and abdominal writhing tests, in mice, at doses that did not impair the motor coordination (15 mg/kg, i.p.). Uliginosin B in high dose (90 mg/kg, i.p.) presented ataxic effect in the rotarod apparatus. These effects seem to be mediated by distinct receptors since the effect on the hot-plate was completely abolished by naloxone and sulpiride, but it was unaffected by SCH 23390. On the other hand, the motor impairment induced by uliginosin B was completely prevented by naloxone and partially prevented by sulpiride and SCH 23390. However, the receptors' activation appears to be indirect since uliginosin B did not bind to opioid and dopaminergic receptors. Thus, uliginosin B effects probably are due to its ability to inhibit monoamine reuptake with consequent activation of dopamine receptors and indirect stimulation of opioid system.