Identification of complement-regulatory membrane protein (Tecrem) in ginbuna carp.
Tecrem ubiquitously expressed on blood cells including CD8α+ and CD4+ lymphocytes.
Coculture with anti-Tecrem mAb inhibited proliferation of PHA-stimulated PBL.
These findings suggest that Tecrem acts as a T-cell moderator.
Teleost complement system may play a role for linking adaptive and innate immunity.