Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation

详细信息    查看全文

• 作者：Yang Xu¹ ; Qilong Wang¹ ; Yingshu Feng¹ ; Caleb Kesse Firempong ; Yuan Zhu ; Emmanuel Omari-Siaw ; Yuanyuan Zheng ; Zunqin Pu ; Ximing Xu ; ^{xmxu@ujs.edu.cn} ; Jiangnan Yu ; ^{yjn@ujs.edu.cn}
• 关键词：[6]-Gingerol ; SMEDDS ; In vitro release ; Pharmacokinetics ; Solubility ; Bioavailability
• 刊名：Journal of Functional Foods
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：27
• 期：Complete
• 页码：703-710
• 全文大小：1493 K
• 卷排序：27

文摘

An effective method for isolating [6]-Gingerol from ginger was established. An optimal formulation of [6]-Gingerol-loaded-SMEDDS was successfully developed. In vitro release profile of [6]-Gingerol from SMEDDS was significantly enhanced. The SMEDDS effectively improved the oral bioavailability of [6]-Gingerol.