Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one in zebrafish embryos in vivo model
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- 作者：Sun Hee Cheonga ; 1 ; Hye-Won Yangb ; 1 ; Eun-Yi Kob ; c ; Ginnae Ahna ; WonWoo Leeb ; Daekyung Kimc ; You-Jin Jeonb ; youjinj@jejunu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Kil-Nam Kimc ; d ; knkim@kbsi.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Trans-1 ; 3-diphenyl-2 ; 3-epoxypropan-1-one (DPEP) ; Anti-inflammatory ; LPS-Treatment ; Zebrafish embryos
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：50
- 期：Complete
- 页码：16-20
- 全文大小：746 K
文摘
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DPEP acts as an effective agent against intracellular ROS formation induced by LPS.
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DPEP effectively inhibited the LPS-induced NO production in zebrafish embryos without toxicity.
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DPEP markedly suppressed the expression of the iNOS and COX-2 enzymes, which generate NO as key mediator of inflammation.
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This is the first report of an anti-inflammatory activity of DPEP in LPS-stimulated zebrafish model.