Evaluation of embryotoxicity for major components of herbal extracts using the chick embryonic heart micromass and mouse D3 embryonic stem cell systems
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- 作者：Omar J. Mohammed ; Muhammad Liaque Latif ; Margaret K. Pratten ; margaret.pratten@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chick embryonic cardiomyocytes ; Micromass ; Mouse D3 embryonic stem cells ; Herbal medicines ; 6-gingerol ; Ginkgolide A ; Ginkgolide B ; Ginsenoside Rg1
- 刊名：Reproductive Toxicology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：117-127
- 全文大小：3734 K
文摘
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Herbal remedies are often used during the early stages of pregnancy.
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Components of selected herbs have been investigated using embryonic cardiomyocytes.
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Gingerol and ginkgolides revealed alterations of some of the endpoints (differentiation, cell viability, protein content).
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Ginsenoside only showed effects at very high concentrations for all endpoints.
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Herbal remedies may not be safe for use in the first trimester of pregnancy.