Potential accumulation of protopanaxadiol-type ginsenosides in six-months toxicokinetic study of SHENMAI injection in dogs

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• 关键词：SHENMAI injection ; Toxicokinetics ; LC&ndash ; MS/MS ; Protopanaxadiol-type ginsenosides ; Protopanaxatriol-type ginsenosides ; Dogs
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：83
• 期：Complete
• 页码：5-12
• 全文大小：1256 K
• 卷排序：83

文摘

The exposure level and TK/PK profile of SMI were obtained in dogs. Great differences were found between the kinetic of PPD and PPT type ginsenosides. Potential accumulation of PPD-type ginsenoside was proved in dogs.