Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands
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- 作者：Enrico Morera ; Luciano De Petrocellis ; Ludovica Morera ; Aniello Schiano Moriello ; Alessia Ligresti ; Marianna Nalli ; David F. Woodward ; Vincenzo Di Marzo ; Giorgio Ortar
- 关键词：Fatty acid amide hydrolase ; FAAH ; Transient receptor potential channels ; TRPV1 ; TRPA1 ; Dual-ligands ; Piperazinyl carbamates
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2009
- 出版时间：1 December 2009
- 年：2009
- 卷：19
- 期：23
- 页码：6806-6809
- 全文大小：448 K
文摘
The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the identification of some ‘dual-action’ compounds targeting both FAAH and TRPV1 or TRPA1 receptors.