Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

详细信息    查看全文

• 作者：Chiara Leoni ; MD¹ ; Roberta Onesimo ; MD¹ ; Valentina Giorgio ; MD² ; Antonella Diamanti ; MD³ ; Daniela Giorgio ; RD¹ ; Lucilla Martini ; MD¹ ; Aurora Rossodivita ; MD¹ ; Marco Tartaglia ; PhD⁴ ; Giuseppe Zampino ; MD¹ ; ^{alipino@alice.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：GH ; Growth hormone ; IGF-1 ; Insulin-like growth factor 1
• 刊名：The Journal of Pediatrics
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：170
• 期：Complete
• 页码：322-324
• 全文大小：175 K

文摘

Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.