Cap-independent protein synthesis is enhanced by betaine under hypertonic conditions

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• 作者：Domenica Carnicelli^a ; Valentina Arfilli^a ; Carmine Onofrillo^a ; Roberta R. Alfieri^b ; Pier Giorgio Petronini^b ; Lorenzo Montanaro^a ; Maurizio Brigotti^a ; ^{maurizio.brigotti@unibo.it}
• 关键词：Betaine ; Compatible osmolytes ; Hyperosmolarity ; 5&prime ; untranslated region ; Protein synthesis ; 48 S pre-initiation complex
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：12 February 2017
• 年：2017
• 卷：483
• 期：3
• 页码：936-940
• 全文大小：628 K
• 卷排序：483

文摘

Under hypertonic conditions, betaine allows recovery and stimulation of translation. Cap-independent translation is driven by 5′-UTR region of mRNA. Betaine enhances 5′-UTR-driven 48 S pre-initiation complex formation. Betaine modulates protein synthesis by favoring cap-independent mRNA recruitment. Proteins involved in stress adaptation are translated by cap-independent mechanisms.