刊名:The Journal of Steroid Biochemistry and Molecular Biology
出版年:2017
出版时间:January 2017
年:2017
卷:165
期:part_PB
页码:438-447
全文大小:1477 K
卷排序:165
文摘
Human aromatase binds the drug sildenafil showing a Type II spectrum. EPR spectroscopy shows that sildenafil does not directly bind heme iron. Sildenafil acts as a mixed and partial inhibitor on human aromatase. Aromatase inhibition by sildenafil is confirmed in ST14A and MCF-7 cells.