Review of thalamocortical resting-state fMRI studies in schizophrenia

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• 作者：Monica Giraldo-Chica ; Ph.D. ; Neil D. Woodward ; Ph.D. ; ^{neil.woodward@vanderbilt.edu}
• 关键词：Schizophrenia ; Thalamus ; Resting-state fMRI ; Cortex
• 刊名：Schizophrenia Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：180
• 期：Complete
• 页码：58-63
• 全文大小：736 K
• 卷排序：180

文摘

Brain circuitry underlying cognition, emotion, and perception is abnormal in schizophrenia. There is considerable evidence that the neuropathology of schizophrenia includes the thalamus, a key hub of cortical-subcortical circuitry and an important regulator of cortical activity. However, the thalamus is a heterogeneous structure composed of several nuclei with distinct inputs and cortical connections. Limitations of conventional neuroimaging methods and conflicting findings from post-mortem investigations have made it difficult to determine if thalamic pathology in schizophrenia is widespread or limited to specific thalamocortical circuits. Resting-state fMRI has proven invaluable for understanding the large-scale functional organization of the brain and investigating neural circuitry relevant to psychiatric disorders. This article summarizes resting-state fMRI investigations of thalamocortical functional connectivity in schizophrenia. Particular attention is paid to the course, diagnostic specificity, and clinical correlates of thalamocortical network dysfunction.