- 作者：Anne Kricker ; Bruce Armstrong ; Vibeke Hansen ; Alan Watson ; Gurpreet Singh-Khaira ; Christophe Lecathelinais ; Chris Goumas ; Afaf Girgis
- 关键词：basal cell carcinoma ; cancer size ; growth rate ; skin cancer ; squamous cell carcinoma
- 刊名：Journal of the American Academy of Dermatology
- 出版年：March, 2014
- 年：2014
- 卷：70
- 期：3
- 页码：456-464
- 全文大小：146 K
Background
Cutaneous basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) have poorer outcomes if treated when large.Objective
We sought to estimate the growth rate of BCCs and SCCs and examine the relationship of personal, pathway, and cancer factors with cancer size (diameter).
Methods
We surveyed patients, pathology, and treatment for invasive BCCs and SCCs in 1 Australian region in 2000 through 2001.
Results
BCC size increased with increasing time since first noticed. Relative to mean size at 0 to 2 months, the mean size ratio was 1.10 at 2 to 8 months and increased steadily to 1.81 at 5 to 10 years (P < .001). Few BCCs were untreated beyond 10 years. There was no consistent evidence that SCC size increased with increasing time. Larger BCCs were independently associated with older age, male sex, no skin checks by a physician, aggressive tumor type, ulceration and lesion-associated scar tissue, and larger SCCs with male sex, skin checks by a physician every 1 to 3 months, and location on limbs.
Limitations
Patient recall of dates and lack of thickness for SCCs are limitations.
Conclusion
Earlier diagnosis of BCCs, perhaps through skin checks by a physician, may reduce their size聽and improve outcome. SCC size did not evidently increase with time.