Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults

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• 作者：Anna Di Landro ; MD^a ; Simone Cazzaniga ; PhD Math^a ; Fabio Parazzini ; MD^b ; Vito Ingordo ; MD^c ; Francesco Cusano ; MD^d ; Laura Atzori ; MD^e ; Francesco Tripodi Cutrì ; MD^f ; Maria Letizia Musumeci ; MD^g ; Cornelia Zinetti ; BS^a ; Enrico Pezzarossa ; MD^h ; Vincenzo Bettoli ; MDⁱ ; Marzia Caproni ; MD^j ; Giovanni Lo Scocco ; MD^k ; Angela Bonci ; MD^l ; Pierluca Bencini ; MD^m ; Luigi Naldi ; MD^a ; ^{luigi.naldi@gised.it} ; GISED Acne Study Group
• 关键词：body mass index ; contraceptive pill ; diet ; fish ; menstrual history ; milk ; moderate to severe acne ; risk factors ; skim milk ; smoking
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：67
• 期：6
• 页码：1129-1135
• 全文大小：117 K

文摘

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Background

Genetic and environmental components may contribute to acne causation.

Objective

We sought to assess the impact of family history, personal habits, dietary factors, and menstrual history on a new diagnosis of moderate to severe acne.

Methods

We conducted a case-control study in dermatologic outpatient clinics in Italy. Cases (205) were consecutive those receiving a new diagnosis of moderate to severe acne. Control subjects (358) were people with no or mild acne, coming for a dermatologic consultation other than for acne.

Results

Moderate to severe acne was strongly associated with a family history of acne in first-degree relatives (odds ratio 3.41, 95 % confidence interval 2.31-5.05). The risk was reduced in people with lower body mass index with a more pronounced effect in male compared with female individuals. No association with smoking emerged. The risk increased with increased milk consumption (odds ratio 1.78, 95 % confidence interval 1.22-2.59) in those consuming more than 3 portions per week. The association was more marked for skim than for whole milk. Consumption of fish was associated with a protective effect (odds ratio 0.68, 95 % confidence interval 0.47-0.99). No association emerged between menstrual variables and acne risk.

Limitations

Some degree of overmatching may arise from choosing dermatologic control subjects and from inclusion of mild acne in the control group.

Conclusions

Family history, body mass index, and diet may influence the risk of moderate to severe acne. The influence of environmental and dietetic factors in acne should be further explored.