Andexanet: Effectively Reversing Anticoagulation

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• 作者：Giuseppe Lippi¹ ; Fabian Sanchis-Gomar² ; ^{fabian.sanchis@uv.es" class="auth_mail" title="E-mail the corresponding author} ; Emmanuel J. Favaloro³
• 关键词：Anticoagulants ; apixaban ; rivaroxaban ; antidote ; andexanet
• 刊名：Trends in Pharmacological Sciences
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：37
• 期：6
• 页码：413-414
• 全文大小：725 K

文摘

Despite direct oral anticoagulants becoming a mainstay of anticoagulant therapy, the effective, timely, and safe reversal of their anticoagulant effect remains challenging. Emerging evidence attests that andexanet, a recombinant and inactive variant of native factor X (FXa), competitively inhibits and counteracts the anticoagulant effect of many inhibitors of native activated FXa.