A MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca2+ Uptake Machinery of Skeletal Muscle
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- 作者：Denis Vecellio Reane1 ; Francesca Vallese1 ; Vanessa Checchetto2 ; Laura Acquasaliente3 ; Gaia Butera1 ; Vincenzo De Filippis3 ; Ildikò ; Szabò ; 2 ; Giuseppe Zanotti1 ; Rosario Rizzuto1 ; 4 ; rosario.rizzuto@unipd.it" class="auth_mail" title="E-mail the corresponding author ; Anna Raffaello1 ; 5 ; anna.raffaello@unipd.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：mitochondrial calcium uptake ; alternative splicing ; skeletal muscle ; mitochondria ; mitochondrial calcium homeostasis ; mitochondrial calcium uniporter
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：64
- 期：4
- 页码：760-773
- 全文大小：2971 K
文摘
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Skeletal muscle mitochondria express a unique MCU complex conserved in vertebrates
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The complex prevalently contains the alternative splice isoform of MICU1, MICU1.1
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MICU1.1-MICU2 heterodimers diminish the Ca2+ activation threshold of MCU
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In skeletal muscle, MICU1.1 is required to amplify ATP supply for contraction