MicroRNA-101 Regulates Multiple Developmental Programs to Constrain Excitation in Adult Neural Networks

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• 作者：Giordano Lippi¹ ; ⁵ ; ^{glippi@ucsd.edu} ; Catarina C. Fernandes¹ ; Laura A. Ewell¹ ; Danielle John¹ ; Benedetto Romoli² ; Giulia Curia² ; Seth R. Taylor¹ ; E. Paxon Frady¹ ; Anne B. Jensen¹ ; Jerry C. Liu¹ ; Melanie M. Chaabane¹ ; Cherine Belal¹ ; Jason L. Nathanson³ ; Michele Zoli² ; Jill K. Leutgeb¹ ; ⁴ ; Giuseppe Biagini² ; Gene W. Yeo³ ; Darwin K. Berg¹ ; ^{dberg@ucsd.edu}
• 关键词：microRNA ; network development ; GABA switch ; NKCC1 ; hyper-excitability ; miR-101 ; excitation/inhibition (E/I) ; synaptogenesis ; target-site blockers ; neurodevelopmental disorders
• 刊名：Neuron
• 出版年：2016
• 出版时间：21 December 2016
• 年：2016
• 卷：92
• 期：6
• 页码：1337-1351
• 全文大小：5273 K
• 卷排序：92

文摘

MiR-101 orchestrates early network development to limit excitation in the adult Transient miR-101 blockade leads to hyper-excitability and memory deficits MiR-101 targets NKCC1 to facilitate the GABA switch and constrains dendrites Ank2 and Kif1a are targeted by miR-101 to limit formation of excitatory synapses