Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency
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- 作者：Adele Mucci1 ; 2 ; 3 ; Jessica Kunkiel1 ; 3 ; Takuji Suzuki4 ; Sebastian Brennig1 ; 2 ; 3 ; Silke Glage5 ; Mark P. Kü ; hnel6 ; Mania Ackermann1 ; 2 ; 3 ; Christine Happle7 ; 8 ; Alexandra Kuhn1 ; 3 ; Axel Schambach3 ; 9 ; Bruce C. Trapnell4 ; Gesine Hansen7 ; 8 ; Thomas Moritz1 ; 3 ; 10 ; Nico Lachmann2 ; 3 ; 10 ; lachmann.nico@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：macrophages ; PAP ; iPSC ; disease modeling ; hematopoiesis
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：9 August 2016
- 年：2016
- 卷：7
- 期：2
- 页码：292-305
- 全文大小：3656 K
文摘
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Myeloid differentiation of murine iPSCs into mature Mφ (iPSC-Mφ)
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Functional iPSC-Mφ similar to bone marrow lineage-negative cell-derived Mφ
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Disease modeling of defects in GM-CSF signaling and Mφ function present in herPAP