Assessment of nickel oxide substituted bioactive glass-ceramic on in vitro bioactivity and mechanical properties

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• 作者：Vikash Kumar Vyas^a ; ^{vkvyas.rs.cer11@itbhu.ac.in} ; Arepalli Sampath Kumar^a ; Akher Ali^a ; Sunil Prasad^a ; Pradeep Srivastava^b ; Sarada Prasanna Mallick^b ; Md Ershad^a ; Saryoo Prasad Singh^a ; Ram Pyare^a
• 关键词：Bioactive glasses ; Bioactive glass ceramics ; Mechanical properties ; Nickel oxide ; FTIR spectrometry and cell culture
• 刊名：Boletín de la Sociedad Española de Cerámica y Vidrio
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：55
• 期：6
• 页码：228-238
• 全文大小：3716 K
• 卷排序：55

文摘

Many type of oxide substituted glass-ceramics like strontium, cobalt, barium and titanium have shown bioactivity with improved mechanical properties. The present work reports the in vitro bioactivity and mechanical properties of nickel oxide substituted in bioactive glass-ceramic and results were compared with 45S5 bioactive glass-ceramic. Bioactive glass ceramics were processed through controlled crystallization of their respective bioactive glasses. The formed crystalline phases in bioactive glass-ceramics were identified using X-ray diffraction (XRD) analysis. The formation of HA layer was assessed by immersing them in the simulated body fluid (SBF) for different soaking periods. The formation of hydroxyapatite was confirmed by FTIR spectrometry, SEM and pH measurement. Densities and mechanical properties of the samples were found to increase considerably with an increasing the concentration of nickel oxide. A decrease in glass transition temperature (Tg) with NiO addition showed that the nickel oxide had acted as an intermediate in smaller quantities in the bioactive glass. The cell culture studies demonstrated that the samples containing low concentration of NiO from 0 to 1.65 mol% were non-cytotoxic against osteoblast cells. Finally, this investigation clearly concluded that NiO doped bioactive glass would be potential biomaterials for biomedical applications.