刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:26 February 2017
年:2017
卷:484
期:1
页码:79-84
全文大小:930 K
卷排序:484
文摘
Hyperglycaemia increases ICAM-1 expression in endothelial cells. ICAM-1 promoter is responsive to the transcription factor specificity protein 1. O-GlcNAc modification has a profound effect on Sp1 activity. O-GlcNAc modification of Sp1 activates transcription and increases ICAM-1 expression.