Role of protein kinase A and class II phosphatidylinositol 3-kinase C2β in the downregulation of KCa3.1 channel synthesis and membrane surface expression by lyso-globotriaosylceramide
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- 作者：Ju Yeon Choi ; Seonghee Park ; sp@ewha.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lyso-globotriaosylceramide ; KCa3.1 channel ; Protein kinase A ; Class II phosphatidylinositol 3-kinase C2β ; Phosphatidylinositol 3-phosphate
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：19 February 2016
- 年：2016
- 卷：470
- 期：4
- 页码：907-912
- 全文大小：1228 K
文摘
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Lyso-Gb3 causes elevation of intracellular cAMP.
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Lyso-Gb3 inhibits the ERK 1/2 phosphorylation through PKA, thereby reducing KCa3.1 channel synthesis.
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Lyso-Gb3 reduces PI3KC2β-mediated intracellular PI(3)P production.
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Lyso-Gb3 reduces both surface and total expression of the KCa3.1 channel.
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Increasing intracellular levels of PI(3)P only recovers the reduced surface expression.