Berberine attenuates high glucose-induced fibrosis by activating the G protein-coupled bile acid receptor TGR5 and repressing the S1P2/MAPK signaling pathway in glomerular mesangial cells
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- 作者：Zhiying Yanga ; c ; 1 ; Jie Lib ; 1 ; Fengxiao Xionga ; Junying Huanga ; Cheng Chena ; Peiqing Liua ; c ; Heqing Huanga ; b ; c ; huangheq@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP-1 ; active protein-1 ; BBR ; berberine ; DN ; diabetic nephropathy ; ERK ; extracellular signal-regulated kinase ; FN ; fibronectin ; GMCs ; glomerular mesangial cells ; ICAM-1 ; intercellular adhesion molecule-1 ; JNK ; c-Jun-NH2-terminal kinase ; MAPK ; mitogen-activated protein kinase ; S1P ; sphingosine 1-phosphate ; S1P2 ; sphingosine 1-phosphate receptor 2 ; Sphk1 ; sphingosine kinase ; TGF-β1 ; transforming growth factor-beta 1 ; TGR5 ; takeda G -protein-coupled receptor 5
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：346
- 期：2
- 页码：241-247
- 全文大小：1468 K
文摘
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Berberine ameliorated diabetic nephropathy in high glucose-cultured glomerular mesangial cells.
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The TGR5 agonist INT-777 decreased the high glucose-induced FN, ICAM-1, and TGF-β1 protein contents.
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TGR5 siRNA partly blocked the renoprotective effects of berberine in high glucose-cultured glomerular mesangial cells.