Integrating structural and mutagenesis data to elucidate GPCR ligand binding
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- 作者：Christian Munk1 ; Kasper Harpsø ; e1 ; Alexander S Hauser ; Vignir Isberg ; David E Gloriam david.gloriam@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Pharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：51-58
- 全文大小：2533 K
文摘
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A wealth of GPCR ligand binding site data is available from structures and mutants.
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Integrating structural and mutant data is a tool to design mutagenesis experiments.
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Ligand molecular interactions are better discriminated by multiple residue mutants.
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New functional and mechanistic insights are keys towards tailored drug actions.