NH125, a commonly used inhibitor of eEF2 kinase, increases protein synthesis.
10 μM NH125 reduces the levels of CPEB3 and increases GluA2 expression.
NH125 at a low concentration fails to alter the expression of CPEB3 and synaptic GluA2.
A selective eEF2 kinase inhibitor, A-484954, reduces peEF2, but not CPEB3 levels.
NH125 has effects that are independent of its ability to inhibit non-eEF2 kinase.