NDRG2 promotes myoblast proliferation and caspase 3/7 activities during differentiation, and attenuates hydrogen peroxide - But not palmitate-induced toxicity
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- 作者：Kimberley J. Anderson ; Aaron P. Russell ; Victoria C. Foletta ; victoria.foletta@deakin.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：NDRG2 ; N-myc downstream-regulated gene 2 ; MRFs ; myogenic regulatory factors ; Cdk ; cyclin-dependent kinase ; Rb ; retinoblastoma ; Myf5 ; myogenic factor 5 ; MyoD ; myogenic differentiation ; p27 ; p27 kip1 ; p21 ; p21 waf1/cip1 ; Akt ; thymoma viral proto-oncogene ; PKCθ ; protein kinase C theta ; SGK1 ; serum- and glucocorticoid-inducible kinase 1 ; Bcl-2 ; B cell leukemia/lymphoma 2 ; Bax ; Bcl-2-associated X protein ; Bcl-xL ; Bcl-2-like 1 ; Mcl-1 ; myeloid cell leukemia 1 ; PARP ; poly (ADP-ribose) polymerase family
- 刊名：FEBS Open Bio
- 出版年：2015
- 出版时间：2015
- 年：2015
- 卷：5
- 期：Complete
- 页码：668-681
- 全文大小：2368 K
文摘
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NDRG2 promotes C2C12 myoblast proliferation but not overall differentiation.
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NDRG2 increases caspase 3/7 activities in differentiating C2C12 muscle cells.
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NDRG2 reduces hydrogen peroxide-induced oxidative and ER stress but not lipotoxicity.
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Ser and Thr residues in the C-terminus of mouse NDRG2 contribute to its function.