Glucokinase expression is regulated by glucose through O-GlcNAc glycosylation
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- 作者：Steffi F. Baldini ; Agata Steenackers ; Sté ; phanie Olivier-Van Stichelen3 ; Anne-Marie Mir ; Marlè ; ne Mortuaire ; Tony Lefebvre1 ; Cé ; line Guinez ; 1 ; 2 ; celine.guinez@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glucokinase ; O-GlcNAcylation ; Liver ; Mouse ; siOGT ; Glucose metabolism
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：16 September 2016
- 年：2016
- 卷：478
- 期：2
- 页码：942-948
- 全文大小：1079 K
文摘
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In vivo, liver glucokinase expression correlate with O-GlcNAc levels.
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Glucokinase expression increases in response to pharmacological inhibition of OGA.
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siRNA-mediated Ogt knock-down decreases glucokinase protein level.
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Glucokinase is modified by O-GlcNAcylation.
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O-GlcNAcylation is a post-translational modification that controls glucokinase expression.