Chemical Constituents from the Rhizomes of Curcuma kwangsiensis

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• 作者：Jun  ; LI^a ;   ; ^b ; Yue  ; LIU^a ;   ; ^b ; Jian-Qiang  ; LI^a ;   ; ^b ; Li-Xia  ; CHEN^a ;   ; ^b ; Feng  ; ZHAO^c ; Feng  ; QIU^a ;   ; ^b ;   ; ^{fengqiu2000@tom.com}
• 关键词：Curcuma kwangsiensis ; Chemical constituents ; Diarylheptanoid ; NO ; Macrophages
• 刊名：Chinese Journal of Natural Medicines
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：9
• 期：5
• 页码：329-333
• 全文大小：403 K
• ISSN：S187553641160071X

文摘

Aim

To study the bioactive constituents of Curcuma kwangsiensis.

Methods

The compounds were isolated by silica gel, Sephadex LH-20, and Rp-18 gel column chromatography, and preparative HPLC. The structures were elucidated by extensive spectroscopic methods including 2D-NMR and HRESI-MS.

Results

Four new compounds, methyl p-(1-β-d-glucopyranosyloxy-1-methylethyl) benzoate (1), p-(1-β-d-glucopyranosyloxy-1-methylethyl) benzoic acid (2), 2, 3, 5-trihydroxy-1-(3-methoxy-4-hydroxyphenyl)-7-(3, 5-dimethoxy-4-hydroxyphenyl) heptane (3), and 2, 3, 5-trihydroxy-1-(4-hydroxyphenyl)-7-(3, 5-dimethoxy-4-hydroxyphenyl) heptane (4), and three known ones, 1, 5-epoxy-3α-hydroxy-1-(3, 4-dihydroxy-5-methoxy-phenyl)-7-(3, 4-dihydroxy) heptane (5), (3R? 5S?-3, 5-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(3, 4-dihydroxyphenyl) heptane (6), and 2, 4, 6-trihydroxyacetophenone-2, 4-di-O-β-d-glucopyranoside (7), were isolated.

Conclusion

Compounds 1? were new natural compounds, and 3?b xmlns="">7 showed strong inhibitory effects on NO production induced by LPS in macrophages.