The neuroprotective potential of low-dose methamphetamine in preclinical models of stroke and traumatic brain injury
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- 作者：Thomas Raua ; John Ziemniakb ; David Poulsenc ; dpoulsen@ubns.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADHD ; attention hyperactive disorder ; AKT ; protein kinase B ; AMPA ; 伪-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; Bcl-2 ; B-cell lymphoma 2 ; BDNF ; brain derived neurotrophic factor ; Css ; Steady state plasma concentration ; D1 ; type 1 dopamine receptor ; D2 ; type 2 dopamine receptor ; DAT ; dopamine transporter ; FDA ; Food and Drug Administration ; IV ; intravenous ; MRI ; magnetic resonance imaging ; NAT ; norepinephrine transporter ; NMDA ; N-methyl-D-aspartate ; OGD ; oxygen glucose deprivation ; PET ; p
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：231-236
- 全文大小：572 K
文摘
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When administered acutely (within 12 hours after injury) low-dose methamphetamine significantly improves cognition and functional behavior.
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The neuroprotective potential of methamphetamine is highly dose dependent.
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Methamphetamine mediates dose dependent neuroprotection when administered within 12 h after severe TBI or stroke.