Inhibitors of ¦Á-glucosidase, ¦Á-amylase and lipase from Chrysanthemum morifolium

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• 作者：Nguyen Thi Luyen ; Le Hoang Tram ; Tran Thi Hong Hanh ; Pham Thanh Binh ; Nguyen Hai Dang ; Chau Van Minh ; Nguyen Tien Dat
• 关键词：Chrysanthemum morifolium ; Asteraceae ; Endoperoxyguainolide ; ¦Á-Glucosidase ; ¦Á-Amylase ; Lipase
• 刊名：Phytochemistry Letters
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：6
• 期：3
• 页码：322-325
• 全文大小：306 K

文摘

A new endoperoxysesquiterpene lactone, 10¦Á-hydroxy-1¦Á,4¦Á-endoperoxy-guaia-2-en-12,6¦Á-olide (1), together with a flavanone, eriodictyol (2), and two flavone glycosides, acacetin-7-O-¦Â-d-glucopyranoside (3) and acacetin-7-O-¦Á-l-rhamopyranoside (4), were isolated from the methanol extract of Chrysanthemum morifolium flowers by a bioassay-guided fractionation. Compound 1 showed strong inhibitory effects against ¦Á-glucosidase and lipase activities, with IC₅₀ values of 229.3 and 161.0 ¦ÌM, respectively. The flavone glycosides 3 and 4 inhibited both ¦Á-glucosidase and ¦Á-amylase, while flavanone 2 was only effective against ¦Á-amylase.