Effects of linagliptin monotherapy compared with voglibose on postprandial blood glucose responses in Japanese patients with type 2 diabetes: Linagliptin Study of Effects on Postprandial blood glucose (L-STEP)

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• 作者：Yoshio Fujitani^a ; ^c ; Shimpei Fujimoto^f ; Kiyohito Takahashi^g ; Hiroaki Satoh^h ; Takahisa Hiroseⁱ ; Toru Hiyoshi^j ; Masumi Ai^k ; Yosuke Okada^l ; Masahiko Gosho^m ; Tomoya Mita^a ; ^d ; Hirotaka Watada^a ; ^b ; ^c ; ^d ; ^e ; ^{hwatada@juntendo.ac.jp}
• 关键词：DPP4 inhibitor ; Alpha-glucosidase inhibitor ; Postprandial hyperglycemia ; Type 2 diabetes mellitus
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：121
• 期：Complete
• 页码：146-156
• 全文大小：805 K
• 卷排序：121

文摘

Here, we conducted a randomized prospective multicenter study that we named the Linagliptin Study of Effects on Postprandial blood glucose (L-STEP) to compare the effects of linagliptin and voglibose on postprandial hyperglycemia. Our data suggested that linagliptin monotherapy had a stronger glucose-lowering effect than voglibose monotherapy with respect to HbA1c and serum fasting glucose levels, but not serum glucose levels 2 h after the start of the meal tolerance test.