Evaluation of two glucuronides resistant to enzymatic hydrolysis as markers of testosterone oral administration

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• 作者：Aristotelis Kotronoulas^a ; ^b ; Alex Gomez-Gomez^a ; Jordi Segura^a ; ^c ; Rosa Ventura^a ; ^c ; Jesú ; s Joglar^b ; Oscar J. Pozo^a ; ^{opozo@imim.es}
• 关键词：3OH-Andros6G ; 6β-glucuronide-3α-hydroxyandrosterone ; 6OH-Andros3G ; 3α-glucuronide-6β-hydroxyandrosterone ; 6OH-Etio3G ; 3α-glucuronide-6β-hydroxyetiocholanolone ; ABP ; athlete biological passport ; Andros ; androsterone ; AndrosG ; andros glucuronide ; d3-EG ; d3-epitestosterone glucuronide ; d3-TG ; d3-testosterone glucuronide ; d4-AndrosG ; d4-androsterone glucuronide ; DWs ; detection windows ; E ; epitestoterone ; EG ; epitestoterone glucuronide ; Etio ; etiocholanolone ; EtioG ; etio glucuronide ; GC&ndash ; MS(/MS)
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：212-218
• 全文大小：892 K
• 卷排序：165

文摘

T metabolites resistant to hydrolysis are evaluated for the screening of oral administration. Four markers including these metabolites increased the detectability of the administration. Prolonged detection of T administration even when urinary TG fails to detect the administration. High intra-individual stability for all evaluated markers.