The N-terminal domain of the GluN3A subunit determines the efficacy of glycine-activated NMDA receptors
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- 作者：Ivana Mesica ; b ; 2 ; Christian Madrya ; 1 ; 2 ; Kirsten Geiderb ; Max Bernhardb ; Heinrich Betza ; c ; Bodo Laubea ; b ; laube@bio.tu-darmstadt.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Excitatory glycine receptor ; N-methyl-d-aspartate receptor ; N-terminal domain ; Receptor structure-function ; Structural model ; Xenopus
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：133-141
- 全文大小：1536 K
文摘
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The GluN3A NTD constitutes a crucial regulatory determinant of GluN1/GluN3A receptor function.
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This is attributed to the selective loss of agonist-evoked auto-inhibition caused by glycine-binding to the GluN1 subunit.
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The GluN3A NTD subunit interface and NTD LBD linker participate in regulating the efficacy of glycine at GluN1/GluN3A receptors.