Differential effects of TM4 tryptophan mutations on inhibition of N-methyl-d-aspartate receptors by ethanol and toluene
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- 作者：C. Thetford Smothers ; John J. Woodward ; woodward@musc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：GluN1 ; GluN2 ; Electrophysiology ; Alcohol ; Inhalants
- 刊名：Alcohol
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：15-19
- 全文大小：1123 K
文摘
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Recombinant NMDARs are inhibited by alcohol or the abused inhalant toluene.
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Tryptophan substitution at a TM4 site in GluN2 subunits reduces inhibition by ethanol.
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Toluene inhibition of NMDARs is unaffected by the TM4 tryptophan mutation.