<p id="par0005">Lentinan treatment led to a robust antidepressant-like effect in the tail suspension test and forced swim test after 60 min of treatment in mice.p>
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<p id="par0010">Dectin-1, the receptor of lentinan, mediated the antidepressant-like effects of lentinan.p>
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<p id="par0015">The prefrontal Dectin-1/AMPA receptor signaling pathway was essential for the robust antidepressant-like effects evoked by lentinan.p>