Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors

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• 作者：Francesco Fazio^a ; ^{francesco_fazio@alice.it} ; Luana Lionetto^b ; Martina Curto^c ; Luisa Iacovelli^d ; Caroline S. Copeland^e ; Stuart A. Neale^f ; Valeria Bruno^a ; ^d ; Giuseppe Battaglia^a ; Thomas E. Salt^g ; Ferdinando Nicoletti^a ; ^d
• 关键词：Cinnabarinic acid ; Xanthurenic acid ; Metabotropic glutamate receptors ; Neuroinflammation ; Schizophrenia
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：112
• 期：part_PB
• 页码：365-372
• 全文大小：356 K
• 卷排序：112

文摘

Cinnabarinic and xanthurenic acids (CA, XA) are neuroactive kynurenines metabolites. CA acts as an orthosteric agonist of mGlu4 receptors. Some in vitro and in vivo effects of XA are mediated by mGlu2/3 receptors. Other targets of CA and XA include the Ah receptor and VGLUT, respectively. CA and XA might have a role in the pathophysiology of CNS disorders.