Nephrotoxicity in rabbits after long-term nandrolone decanoate administration
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- 作者：Christina Tsitsimpikoua ; 1 ; Fotini Vasilakib ; 1 ; Konstantinos Tsarouhasc ; Persefoni Fragkiadakib ; Maria Tzardid ; Nikolaos Goutzourelasf ; Charitini Nepkae ; Alexandra Kalogerakid ; Ioannis Heretisg ; Zoi Epitropakif ; Dimitrios Kouretasf ; Aristidis M. Tsatsakisb ; toxlab@med.uoc.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAS ; anabolic androgenic steroids ; SGOT ; serum glutamil oxaloacetic transaminase ; SGPT ; serum glutamic pyruvic transaminase ; ALP ; alkaline phospatase ; γGT ; serum gamma-glutamyltransferase ; TBARS ; thiobarbituric acid reactive substances ; TAC ; total antioxidant capacity ; GSH ; glutathione
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：259
- 期：Complete
- 页码：21-27
- 全文大小：1084 K
文摘
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Nephrotoxic effects of nandrolone decanoate on young rabbits.
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Significant increase in serum urea and creatinine.
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Hypereamia, fibrosis and focal inflammation in kidney tissue of high-dosed rabbits.
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Increased telomerase activity in intramuscularly treated animals.
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Tissue TBARS and GSH levels were significantly altered.