Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase

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• 作者：Junmin Zhang^a ; ^b ; Juan Yao^a ; Shoujiao Peng^a ; Xinming Li^a ; Jianguo Fang^a ; ^{fangjg@lzu.edu.cn}
• 关键词：Thioredoxin ; Securinine ; Redox homeostasis ; Oxidative stress ; Apoptosis ; Reactive oxygen species
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：129-138
• 全文大小：1310 K
• 卷排序：1863

文摘

CNS drug securinine (SCR) inhibits thioredoxin reductase (TrxR). Knockdown or pharmacological inhibition of TrxR enhances cytotoxicity of SCR. SCR promotes elevation of oxidized glutathione and thioredoxin in cells. SCR elicits oxidative stress-mediated apoptosis of HeLa cells. Targeting TrxR by SCR provides a novel mechanism for its anticancer activity.