Bioactivity-guided identification of antimicrobial metabolites in Alnus glutinosa bark and optimization of oregonin purification by Centrifugal Partition Chromatography
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- 作者：Amin Abedinia ; b ; 1 ; Sé ; bastien Cholleta ; c ; 1 ; Apostolis Angelisa ; d ; Nicolas Boriea ; Jean-Marc Nuzillarda ; Alexios-Leandros Skaltsounisd ; Romain Reynaude ; Sophie C. Gangloffb ; Jean-Hugues Renaulta ; Jane Huberta ; jane.hubert@univ-reims.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alnus glutinosa ; Oregonin ; Antimicrobial activity ; Centrifugal partition extraction ; NMR-based dereplication
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：1029-1030
- 期：Complete
- 页码：121-127
- 全文大小：1559 K
文摘
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The antimicrobial activity of a bark extract of <em>Alnus glutinosaem> was studied.
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This bark extract was fractionated by Centrifugal Partition Chromatography.
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The major extract constituents were identified by 13C NMR dereplication.
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Oregonin was identified as the major and most active compound of the extract.
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Purification of oregonin was optimized at the laboratory-scale by CPC.