Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis

详细信息    查看全文

• 作者：Ian Cumpstey^a ; ^b ; ^{ian.cumpstey@sjc.oxon.org"" rel=""nofollow} ; Clinton Ramstadius^a ; K. Eszter Borbas^a ; Dominic S. Alonzi^c ; Terry D. Butters^c
• 关键词：α ; -Glucosidase II ; Glycosidase inhibitors ; Valienamine ; Pseudodisaccharides ; N-Glycans
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2011
• 出版时间：15 September 2011
• 年：2011
• 卷：21
• 期：18
• 页码：5219-5223
• 全文大小：405 K

文摘

Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for α-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(α1→3)Glc and Glc(α1→3)Man disaccharides representing the linkages cleaved by α-Glucosidase II in N-glycan biosynthesis. These (N1→3)-linked pseudodisaccharides were found to have some α-Glucosidase II inhibitory activity, while two other (N1→6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme.