Characterization and application of roxithromycin loaded cyclodextrin based nanoparticles for treatment of multidrug resistant bacteria
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- 作者：Farha Masooda ; farha.masood@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Tariq Yasinb ; Habib Bukharia ; Muhammad Mujahidc
- 关键词：Antimicrobial activity ; Cyclodextrin ; Inclusion complex ; Nanoparticles ; Poly-(lactic-co-glycolic acid) ; Roxithromycin
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：1-7
- 全文大小：1681 K
文摘
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Designed drug-delivery systems against multidrug resistant (MDR) bacteria
Cyclodextrin–roxithromycin (CD-ROX) inclusion complexes were formed.
The inclusion complexes were then loaded into poly-lactic-co-glycolic acid (PLGA).
The resulting CD-ROX/PLGA nanoparticles were characterized.
All delivery systems showed antimicrobial activity against selected MDR bacteria.