Delivery of an inactivated avian influenza virus vaccine adjuvanted with poly(D,L-lactic-co-glycolic acid) encapsulated CpG ODN induces protective immune responses in chickens
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- 作者：Shirene M. Singh shirene@uoguelph.ca" class="auth_mail" title="E-mail the corresponding author ; Tamiru N. Alkie talkie@uoguelph.ca" class="auth_mail" title="E-mail the corresponding author ; É ; va Nagy enagy@uoguelph.ca" class="auth_mail" title="E-mail the corresponding author ; Raveendra R. Kulkarni kulkarnr@uoguelph.ca" class="auth_mail" title="E-mail the corresponding author ; Douglas C. Hodgins dhodgins@uoguelph.ca" class="auth_mail" title="E-mail the corresponding author ; Shayan Sharif ; shayan@uoguelph.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Avian influenza virus ; Chickens ; CpG ODN ; Poly(D ; L-lactic-co-glycolic acid) ; Delivery system ; Nanoparticle ; Immune response
- 刊名：Vaccine
- 出版年：2016
- 出版时间：14 September 2016
- 年：2016
- 卷：34
- 期：40
- 页码：4807-4813
- 全文大小：960 K
文摘
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Immunogenicity of PLGA nanoparticle-encapsulated AIV formulations was evaluated.
Nonencapsulated AIV plus encapsulated CpG resulted in higher antibody responses.
Nonencapsulated AIV plus encapsulated CpG caused a reduction in virus shedding.