Single step electrohydrodynamic atomization was used to produce cisplatin encapsulated PLGA polymer particles.

The versatility of the method in controlling the size and drug loading of the particles by variation of drug:polymer ratios and operating conditions was demonstrated.

Compared to conventional nanoparticle production methods, particles generated by electrohydrodynamic atomization proved to have higher encapsulation efficiencies (> 70%).

The distribution of the drug with various concentrations within the polymeric particles was further studied with SEM-TEM/EDX methods and compared against the unloaded particles.

In-vitro release data were analysed and it was shown that all the formulations tested exhibited an initial burst release followed by a sustained release period.

While the release data fit best with the Ritger-Peppas model, it was shown that it is not possible to attribute the largest difference in initial release rate entirely to particle size.

This study highlights the enhanced functionality due to particle morphology and drug concentration, which enables the potential for high cisplatin encapsulation and tunable release.