Immunoreceptors on neutrophils
详细信息 查看全文
- 作者：Dieke J. van Reesa ; Katka Szilagyia ; Taco W. Kuijpersa ; b ; Hanke L. Matlunga ; Timo K. van den Berga ; t.k.vandenberg@sanquin.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADCC ; antibody-dependent cellular cytotoxicity ; ANCAs ; anti-neutrophil autoantibodies ; Btk ; Bruton's tyrosine kinase ; DAG ; diacyl-glycerol ; DAP12 ; DNAX activation protein of 12 ; kDa ; ERK ; extracellular signal-regulated kinase ; fMLP ; N-Formylmethionine-leucyl-phenylalanine ; GBS ; group B Streptococci ; GEF ; guanine nucleotide exchange factor ; GPCR ; G protein-coupled receptor ; GPI ; glycophosphatidylinositol ; Grb2 ; growth factor receptor-bound protein 2 ; IgSF ; Immunoglobulin superfamily ; IP3 ; ino
- 刊名：Seminars in Immunology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：28
- 期：2
- 页码：94-108
- 全文大小：2813 K
文摘
- •
Neutrophil activities must be tightly controlled to maintain immune homeostasis.
- •
Activating and inhibitory receptors balance the outcome of immune cell activation.
- •
Immunoreceptors contain Ig-like extracellular domains and signal via ITAMs or ITIMs.
- •
Syk or SHP/SHIP mediate downstream signaling after immunoreceptor activation.
- •
Targeting immunoreceptors provides opportunities for therapeutic interventions.