Endoplasmic reticulum-derived reactive oxygen species (ROS) is involved in toxicity of cell wall stress to Candida albicans
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- 作者：Qilin Yua ; Bing Zhanga ; Jianrong Lia ; Biao Zhangb ; Honggang Wanga ; Mingchun Lia ; nklimingchun@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ROS ; reactive oxygen species ; OSR ; oxidative stress response ; MMP ; mitochondrial membrane potential ; VMP ; vacuolar membrane permeabilization ; C-DCFDA ; 5-(6)-carboxy-2&prime ; 7&prime ; -dichlorofluorescein diacetate ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorofluorescin diacetate ; ER ; endoplasmic reticulum ; CWI ; cell wall integrity ; BIP ; 2 ; 2&prime ; -bipyridyl ; UPR ; unfolded protein response ; GPI-CWP ; glycophosphatidylinositol-cell wall protein ; ERES ; endoplasmic reticulum exit site ; MAPK ; mitogen-activated
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：572-583
- 全文大小：3081 K
文摘
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ROS scavengers attenuate the toxicity of cell wall stress to C. albicans.
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Cell wall stress causes ROS accumulation and activation of OSR.
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Cell wall stress has an impact on ER function and enhances protein secretion.
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Ero1 oxidation in the ER is involved in cell wall stress-caused ROS production.