Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response
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- 作者：Monika Majchrzak-Goreckaa ; 1Author Vitae ; Pawel Majewskia ; 1Author Vitae ; Beata GrygieraAuthor Vitae ; Krzysztof MurzynbAuthor Vitae ; Joanna Cichya ; Joanna.Cichy@uj.edu.pl" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：AHR ; airway hyperresponsiveness ; ALS ; amyotrophic lateral sclerosis ; CHIP ; chromatin immunoprecipitation ; CNS ; central nervous system ; COX ; cyclooxygenase ; HMG-1 ; high-mobility group 1 ; HSV ; herpes simplex virus ; ECM ; extracellular matrix ; IGFBP-3 ; insulin like growth factor binding protein-3 ; IFNI ; type I interferons ; LOX ; lysyl oxidase ; MAG ; myelin-associated glycoprotein ; MMP ; metalloproteinase ; NSC ; neural stem cells ; NE ; neutrophil elastase ; NET ; neutrophil extracellular trap ; OVA ; ovalbumi
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：28
- 期：Complete
- 页码：79-93
- 全文大小：1224 K
文摘
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SLPI plays a critical role in regulating host defense responses through multiple mechanisms.
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SLPI restrains excessive responses to microbiota at epithelial body barriers.
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SLPI controls microbial infection through its effects on microbes and the host.
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SLPI exhibits anti-inflammatory properties in allergy and autoimmunity.
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SLPI controls key steps of wound healing.
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SLPI regulates cell renewal, differentiation and apoptosis.